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Formylation of Amines by CO2 Hydrogenation Using Preformed Co(II)/Nickel(II) Complexes

Mohammad A Affan1, Gabriele Schatte1, Philip G Jessop1

  • 1Department of Chemistry, Queen's University, 90 Bader Lane, Chernoff Hall, Kingston Ontario K7L 3N6, Canada.

Inorganic Chemistry
|September 22, 2020
PubMed

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Nitriles can be reduced to primary amines using reducing agents like lithium aluminum hydride or catalytic hydrogenation. The reduction introduces an amino group with an extra carbon in the skeleton. Nitriles are formed from the reaction between alkyl halides and sodium cyanide through the SN2 mechanism. Primary alkyl halides are the preferred substrates to prepare nitriles.
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