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Updated: Dec 8, 2025

Porcine Model of Infrarenal Abdominal Aortic Aneurysm
Published on: November 21, 2019
The role of autophagy in abdominal aortic aneurysm: protective but dysfunctional
Lei Wang1, Shuai Liu1, Baihong Pan1
1Department of General &vascular Surgery, Xiangya Hospital, Central South University , Changsha, Hunan, China.
Abstract:
Autophagy, an evolutionarily conserved mechanism that promotes cell survival by recycling nutrients and degrading long-lived proteins and dysfunctional organelles, is an important defense mechanism, and its attenuation has been well documented in senescence and aging-related diseases. Abdominal aortic aneurysm (AAA), a well-known aging-related disease, has been defined as a chronic degenerative process in the abdominal aortic wall; however, the complete mechanism is unknown, and a clinical treatment is lacking. Accumulating evidence has recently revealed that numerous drugs that can induce autophagy are effective in the treatment of AAA. The purpose of this systematic review was to focus on the cross-talk between autophagy and high-risk factors and the potential pathogenesis of AAA to understand not only the host defense and pathogenesis but also potential treatments.
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