Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue specificity in nerve regeneration.

G Lundborg, L B Dahlin, N Danielsen

    Scandinavian Journal of Plastic and Reconstructive Surgery
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ulnar nerve dislocation in ulnar nerve entrapment at the elbow. Influence on surgical outcome.

    Hand surgery & rehabilitation·2021
    Same author

    Association between HbA<sub>1c</sub> and peripheral neuropathy in a 10-year follow-up study of people with normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes.

    Diabetic medicine : a journal of the British Diabetic Association·2017
    Same author

    Congenital thumb anomalies and the consequences for daily life: patients' long-term experience after corrective surgery. A qualitative study.

    Disability and rehabilitation·2016
    Same author

    One-year results of needle fasciotomy and collagenase injection in treatment of Dupuytren's contracture: A two-centre prospective randomized clinical trial.

    The Journal of hand surgery, European volume·2015
    Same author

    Long-term results of syndactyly correction by the trilobed flap technique focusing on hand function and quality of life.

    The Journal of hand surgery, European volume·2015
    Same author

    Professor Nils Carstam, MD, PhD, 13 September 1913-28 May 2014.

    The Journal of hand surgery, European volume·2014

    Axonal growth shows tissue specificity, preferring nerve tissue over other grafts in regeneration experiments. This finding challenges previous research on neurotropism in nerve repair.

    Area of Science:

    • Neuroscience
    • Regenerative Medicine
    • Tissue Engineering

    Background:

    • The concept of neurotropism in nerve regeneration, suggesting nerves grow towards specific chemical attractants, has been debated.
    • Previous studies by Weiss & Taylor in 1944 presented evidence against neurotropism.
    • Understanding the directional cues for axonal growth is crucial for effective nerve repair strategies.

    Purpose of the Study:

    • To re-evaluate the phenomenon of neurotropism in nerve regeneration.
    • To investigate the directional preference of axonal growth using a novel experimental setup.
    • To determine if nerve tissue exhibits a specific attractant property for regenerating axons.

    Main Methods:

    • A silicone Y-chamber system was employed to guide regenerating rat sciatic nerve axons.

    Related Experiment Videos

  • The proximal nerve stump was connected to the Y-chamber, with distal outlets configured with either a nerve graft, tendon graft, or left empty/plugged.
  • Axonal growth patterns were analyzed after 4 and 12 weeks.

    • Main Results:

    • Axonal growth demonstrated a strong preferential or exclusive direction towards the nerve graft in all experimental conditions.
    • This directional growth was observed regardless of whether the alternative outlet contained a tendon graft or was occluded.
    • The findings contradict the earlier conclusions of Weiss & Taylor regarding neurotropism.

    Conclusions:

    • The study provides evidence for "tissue specificity" in nerve regeneration, where axons preferentially grow towards nerve tissue.
    • This suggests the presence of specific factors within the distal nerve stump or associated matrix that guide axonal regeneration.
    • Further research is needed to elucidate the humoral, cellular, and molecular mechanisms underlying this observed tissue specificity.