Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

1.0K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.0K
Association Areas of the Cortex01:21

Association Areas of the Cortex

8.1K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
8.1K
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

134
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
134
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

96
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
96
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

119
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
119
Binge Eating Disorders01:23

Binge Eating Disorders

336
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
336

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Betrayal and unfairness are linked through insula-valuation network dynamics.

bioRxiv : the preprint server for biology·2026
Same author

Differences in other-directed emotion regulation tracks connectivity between amygdala and prefrontal regions during fairness decisions.

bioRxiv : the preprint server for biology·2026
Same author

Fraud in the Age of AI: Commentary on "The Scammers' Psychological Warfare".

Psychological science in the public interest : a journal of the American Psychological Society·2026
Same author

Association of Air Pollution and Socioeconomic Deprivation with Depression and Pain.

International journal of environmental research and public health·2026
Same author

Contributions of default mode network to subjective valuation and maladaptive decision making.

Current opinion in behavioral sciences·2026
Same author

Striatal Social Reward Sensitivity Predicts Trust-Related Brain Responses Depending on Closeness and Depression.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Dec 8, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

708

Obesity is associated with reduced orbitofrontal cortex volume: A coordinate-based meta-analysis.

Eunice Y Chen1, Simon B Eickhoff2, Tania Giovannetti1

  • 1Department of Psychology, Temple University, USA.

Neuroimage. Clinical
|September 22, 2020
PubMed
Summary

Greater body mass index is linked to reduced gray matter in the right orbitofrontal cortex. This brain region

Keywords:
BMIBody mass indexGray matter volumeObesityOverweightVBM

More Related Videos

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

76.0K
Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
10:51

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Published on: January 20, 2012

21.6K

Related Experiment Videos

Last Updated: Dec 8, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

708
Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

76.0K
Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety
10:51

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Published on: January 20, 2012

21.6K

Area of Science:

  • Neuroimaging
  • Obesity Research
  • Brain Structure and Function

Background:

  • Neural models of obesity often focus on prefrontal and striatal differences.
  • Previous studies on orbitofrontal cortex (OFC) and obesity have yielded mixed results.
  • Meta-analyses of functional neuroimaging lack a clear OFC-obesity link, while structural studies show inconsistent findings.

Purpose of the Study:

  • To clarify the relationship between brain structure and obesity.
  • To investigate associations between body mass index (BMI) and gray matter volume in the orbitofrontal cortex.
  • To explore the functional network associated with the orbitofrontal cortex in obesity.

Main Methods:

  • Conducted a meta-analysis of 25 voxel-based morphometry studies.
  • Utilized Neurosynth Network Coactivation analysis with the right OFC as a seed region.
  • Applied findings to Human Connectome Project data for functional analysis.

Main Results:

  • Increased BMI was associated with decreased gray matter volume in the right orbitofrontal cortex (Brodmanns' areas 10 and 11).
  • The right OFC is functionally connected to regions including the left frontal medial cortex and right precuneus cortex.
  • Higher BMI correlated with increased activity in the left frontal medial cortex during a gambling task (p < .05).

Conclusions:

  • Orbitofrontal cortex structure and function are crucial in neural models of obesity.
  • Reduced gray matter volume in the right OFC is linked to higher BMI.
  • Further longitudinal research is needed to understand the functional significance and dynamic changes of OFC gray matter in obesity.