The clinical relevance of the microbiome when managing paediatric infectious diseases-Narrative review

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Talía Sainz1,2, Jaime Delgado1,2, Ana Mendez-Echevarría1,2

  • 1Hospital La Paz and La Paz Research Intitute (IdiPAZ), Madrid, Spain.

Acta Paediatrica (Oslo, Norway : 1992)
|September 22, 2020
PubMed

Insights

The human microbiome significantly impacts infectious diseases in children. This review explores microbiome research for preventing, diagnosing, and treating pediatric infections, highlighting clinical practice integration needs.

Area of Science:

  • Microbiology
  • Immunology
  • Pediatrics

Background:

  • The human microbiome's role in health and disease is increasingly recognized.
  • The interaction between the microbiota and the immune system has profound implications for infectious diseases.
  • Understanding the pediatric microbiome is crucial for addressing infectious disease challenges.

Purpose of the Study:

  • To provide a comprehensive overview of the influence of the microbiome on infectious diseases in children.
  • To summarize current evidence on microbiome research in pediatric infectious disease prevention, diagnosis, and treatment.

Main Methods:

  • Systematic review of existing literature on the pediatric microbiome and infectious diseases.
  • Analysis of findings related to prevention, diagnosis, and treatment strategies.
  • Focus on translating microbiome knowledge into clinical practice.

Main Results:

  • The microbiome plays a significant role in various pediatric infectious diseases.
  • Current research reveals potential applications in disease prevention and diagnosis.
  • Treatment strategies incorporating microbiome modulation show promise.

Conclusions:

  • Significant research gaps remain in understanding the pediatric microbiome's influence on infections.
  • Integrating microbiome-based insights into routine pediatric clinical practice is essential.
  • Further research is needed to fully leverage microbiome knowledge for improved child health outcomes.
Keywords:
childreninfectious diseasesmicrobiomemicrobiotapre- and probiotics

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