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Design of Paracetamol Delivery Systems Based on Functionalized Ordered Mesoporous Carbons
Joanna Goscianska1, Aleksander Ejsmont1, Anna Olejnik1
1Department of Chemical Technology, Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Materials (Basel, Switzerland)
|September 23, 2020
Summary
Oxidized mesoporous carbons effectively deliver paracetamol (an analgesic and antipyretic). Functionalized carbons show enhanced drug adsorption and release, with hexagonal structures proving optimal for drug delivery systems.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Ordered mesoporous carbons (OMCs) are advanced materials with tunable structures.
- Paracetamol is a widely used analgesic and antipyretic drug.
- Developing efficient drug delivery systems is crucial for pharmaceutical applications.
Purpose of the Study:
- To investigate the use of oxidized OMCs as novel delivery systems for paracetamol.
- To evaluate the impact of oxidation and structural properties on paracetamol adsorption and release.
- To determine the optimal OMC structure for enhanced paracetamol loading and controlled release.
Main Methods:
- Synthesis of cubic and hexagonal OMCs using soft and hard templating methods.
- Oxidation of OMCs using an acidic ammonium persulfate solution.
- Characterization of surface functional groups, specific surface area, and pore volume.
- Evaluation of paracetamol adsorption kinetics (pseudo-first- and pseudo-second-order models) and isotherms (Langmuir model).
- Assessment of paracetamol release profiles from functionalized OMCs.
Main Results:
- Oxidation reduced surface area and pore volume but increased acidic oxygen-containing functional groups.
- Paracetamol adsorption occurred via donor-acceptor complexes and hydrogen bonding, following Langmuir isotherms and pseudo-second-order kinetics.
- Oxidized OMCs demonstrated enhanced paracetamol adsorption capacity and release rates compared to pristine samples.
- Hexagonal OMCs synthesized via the hard template method exhibited the optimal drug loading capacity and release pattern.
Conclusions:
- Oxidized ordered mesoporous carbons are promising carriers for paracetamol delivery.
- Surface functional groups and textural parameters significantly influence drug adsorption and release.
- Hexagonal OMCs produced by hard templating offer superior performance for paracetamol delivery systems.
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