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Chronic duodenal and gastric ulcer
The Surgical Clinics of North America
|June 1, 1987
Summary
Advances in gastric physiology and cellular biology have improved antiulcer drug options. Future peptic ulcer treatment will involve tailored medical and surgical approaches.
Area of Science:
- Gastroenterology
- Pharmacology
- Cellular Biology
Background:
- Significant progress in understanding gastric physiology over the last 20 years.
- Cellular biology advancements have accelerated gastric pharmacology.
- A wide array of antiulcer drugs are now available for clinical use.
Purpose of the Study:
- To review the current state of knowledge in gastric physiology and pharmacology.
- To discuss the therapeutic options for peptic ulceration.
- To outline future directions in managing peptic ulcer disease.
Main Methods:
- Review of recent advances in basic gastric physiology.
- Analysis of progress in gastric pharmacology.
- Discussion of clinical implications for peptic ulcer treatment.
Main Results:
- Major advances in understanding basic gastric physiology.
- Rapid progress in gastric pharmacology driven by cellular biology.
- A large and growing list of antiulcer drugs is available.
Conclusions:
- Effective management of peptic ulceration requires understanding pathophysiology and treatment limitations.
- Selective drug use and individualized regimens are crucial.
- Future management will likely combine tailored medical and surgical treatments.