Acute bilateral myopia induced by Triplixam: a case report

Area of Science:

• Ophthalmology
• Cardiology
• Pharmacology

Background:

• Systemic hypertension is commonly treated with medications like Triplixam.
• Adverse ocular side effects from systemic hypertension drugs are rare.
• Triplixam contains amlodipine, indapamide, and perindopril arginine.

Observation:

• A 33-year-old male presented with acute bilateral blurred vision.
• Examination revealed myopia, lens thickening, choroidal effusion, and macular striae.
• These ocular changes were associated with the use of Triplixam.

Findings:

• The patient's symptoms and objective findings resolved completely after discontinuing Triplixam.
• The myopia was likely caused by indapamide-induced ciliary body reaction leading to lens thickening and refractive index changes.
• Retinal striae were attributed to the volume effect of choroidal effusion.

Implications:

• This case highlights a potential, albeit uncommon, adverse ocular effect of Triplixam, likely due to its indapamide component.
• Physicians, including cardiologists and general practitioners, should be aware of this possible side effect when prescribing Triplixam for hypertension.
• Prompt recognition and drug discontinuation can lead to complete resolution of these visual disturbances.