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Relationship between high-sensitivity C reactive protein and the risk of gallstone disease: results from the Kailuan

Tong Liu1, Sarah Tan Siyin2, Nan Yao1

  • 1Department of General Surgery, Aerospace Central Hospital, Beijing, China.

BMJ Open
|September 23, 2020
PubMed

Insights

Elevated high-sensitivity C-reactive protein (hs-CRP) is an independent risk factor for new gallstone disease (GSD). This finding suggests hs-CRP may help identify individuals at higher risk for GSD development.

Area of Science:

  • Biomedical research
  • Clinical epidemiology
  • Inflammation markers

Background:

  • Gallstone disease (GSD) is linked to obesity, dyslipidemia, and poor diet.
  • These factors are associated with elevated high-sensitivity C-reactive protein (hs-CRP) levels.
  • The independent role of hs-CRP in GSD development remains unclear.

Purpose of the Study:

  • To prospectively investigate the association between hs-CRP concentrations and the incidence of GSD.
  • To determine if hs-CRP is an independent risk factor for GSD.
  • To assess the predictive value of hs-CRP in identifying new GSD cases.

Main Methods:

  • Prospective cohort study involving 95,319 participants free from GSD.
  • Collection of epidemiological, anthropometric, and biochemical data.
  • Cox proportional hazards regression models used to analyze the association between hs-CRP and GSD risk, adjusting for confounders.

Main Results:

  • Over a mean follow-up of 7.58 years, 4205 new GSD cases were identified.
  • Elevated hs-CRP concentrations (1-3 mg/L and >3 mg/L) were significantly associated with increased GSD risk (HRs 1.11 and 1.12, respectively).
  • Multivariate models including hs-CRP showed improved fitness and predictive value for GSD identification.

Conclusions:

  • Elevated hs-CRP concentration is an independent risk factor for new-onset GSD in the Chinese population.
  • hs-CRP may serve as a valuable biomarker for predicting GSD risk.
  • Further research can explore hs-CRP's role in GSD pathogenesis and prevention strategies.
Abstract

Keywords:
gastroenterologymotility disorderspublic health

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