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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Published on: June 10, 2025

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Cutaneous vasculitis in SLE.

Romy Kallas1, Daniel Goldman2, Michelle A Petri3

  • 1Division of Rheumatology, Johns Hopkins Medicine, Baltimore, Maryland, USA kallasr@mlhs.org.

Lupus Science & Medicine
|September 23, 2020
PubMed
Summary
This summary is machine-generated.

Cutaneous small vessel vasculitis affects 17.3% of Systemic Lupus Erythematosus patients and is more common in African-Americans. Clinical factors like myositis and anemia predict its development, which is linked to greater organ damage.

Keywords:
autoantibodiesinflammationlupus erythematosussystemic

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Area of Science:

  • Rheumatology
  • Immunology
  • Dermatology

Background:

  • Cutaneous small vessel vasculitis is a clinical manifestation in Systemic Lupus Erythematosus (SLE).
  • Understanding predictors of cutaneous vasculitis in SLE is crucial for patient management.

Purpose of the Study:

  • To determine the temporal association between clinical and serological manifestations and the development of cutaneous small vessel vasculitis in a large, multiethnic SLE cohort.
  • To identify risk factors and clinical predictors for cutaneous small vessel vasculitis in SLE patients.

Main Methods:

  • Prospective cohort study of 2580 SLE patients diagnosed by SLICC or ACR criteria.
  • Kaplan-Meier analysis and Cox regression were used to assess associations between disease manifestations and cutaneous vasculitis development, adjusting for demographics.
  • Cutaneous small vessel vasculitis was identified clinically as part of the Systemic Lupus Erythematosus Disease Activity Index.

Main Results:

  • Cutaneous small vessel vasculitis occurred in 17.3% of patients, with a mean onset of 4.78 years post-SLE diagnosis.
  • Discoid rash, Raynaud's phenomenon, myositis, anemia, Coombs' positivity, leukopenia, anti-Smith, and anti-RNP antibodies were significantly associated with cutaneous vasculitis.
  • African-Americans had a higher risk compared to Caucasians, and 35% of patients experienced recurrences.

Conclusions:

  • Cutaneous vasculitis is a frequent and often recurrent complication in SLE patients.
  • Myositis and hematological manifestations are significant predictors of cutaneous vasculitis development.
  • The presence of cutaneous vasculitis is associated with increased organ damage in SLE.