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The Cytokine Expression in Patients with Cardiac Complication after Immune Checkpoint Inhibitor Therapy

Toshihiro Tsuruda1, Naoki Yoshikawa2, Motoaki Kai1

  • 1Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan.

Internal Medicine (Tokyo, Japan)
|September 23, 2020
PubMed

We herein report the cytokine expression at different stages for three patients who developed cardiac complications after immune checkpoint inhibitor (ICI) therapy. Case 1 with biopsy-proven myocarditis showed increased levels of interleukin (IL)-8, monocyte chemotactic and activating factor, and granulocyte macrophage colony-stimulating factor (GM-CSF) when he developed Takotsubo cardiomyopathy. Case 2 with subclinical myocarditis showed predominant activation of IL-8 during the progressive clinical course. Case 3 with cytokine-releasing syndrome showed substantial activations of IL-6, IL-8, GM-CSF, and interferon-γ. Our data suggest the development of unique cytokine activation in individual patients with cardiac complications after ICI therapy.

Keywords:
cancercytokine releasing syndromemyocarditistroponin

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