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Secondary Minimal Change Disease Due to Pancreatic Cancer Improved by Chemotherapy
Sakue Masuda1, Kazuya Koizumi1, Hidekazu Moriya2
1Department of Gastroenterology Medicine Center, Shonan Kamakura General Hospital, Japan.
Abstract:
We herein describe an 82-year-old patient who presented with proteinuria and systemic edema. He was diagnosed with minimal change disease (MCD) and was found to have stage III pancreatic cancer. He could not undergo surgical resection due to invasion to the celiac artery and he was thus treated with chemotherapy. After a month of chemotherapy, his proteinuria improved to a normal level. After two months of chemotherapy, computed tomography indicated a partial response to the therapy. MCD can occur as paraneoplastic syndrome in patients with malignant disease, and chemotherapy can be effective for MCD associated with paraneoplastic syndrome.
Insights
Minimal change disease (MCD) in an 82-year-old patient resolved with chemotherapy for stage III pancreatic cancer. This case highlights chemotherapy
Area of Science:
- Nephrology
- Oncology
- Internal Medicine
Background:
- Minimal change disease (MCD) is a common cause of nephrotic syndrome.
- MCD can present as a paraneoplastic syndrome in patients with malignancies.
Observation:
- An 82-year-old male presented with proteinuria and systemic edema.
- The patient was diagnosed with stage III pancreatic cancer and minimal change disease.
Findings:
- Chemotherapy for pancreatic cancer led to the resolution of proteinuria within one month.
- Computed tomography confirmed a partial response to chemotherapy after two months.
Implications:
- Chemotherapy can be an effective treatment for minimal change disease associated with paraneoplastic syndrome.
- This case underscores the importance of considering paraneoplastic syndromes in patients with unexplained nephrotic syndrome and malignancy.
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