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Published on: March 9, 2019
Prediction of independence in bowel function after spinal cord injury: validation of a logistic regression model
Omar Khan1, Jetan H Badhiwala1,2, Michael G Fehlings3,4
1Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Study Design:
Retrospective analysis of prospectively collected data.
Objectives:
Recently, logistic regression models were developed to predict independence in bowel function 1 year after spinal cord injury (SCI) on a multicenter European SCI (EMSCI) dataset. Here, we evaluated the external validity of these models against a prospectively accrued North American SCI dataset.
Setting:
Twenty-five SCI centers in the United States and Canada.
Methods:
Two logistic regression models developed by the EMSCI group were applied to data for 277 patients derived from three prospective multicenter SCI studies based in North America. External validation was evaluated for both models by assessing their discrimination, calibration, and clinical utility. Discrimination and calibration were assessed using ROC curves and calibration curves, respectively, while clinical utility was assessed using decision curve analysis.
Results:
The simplified logistic regression model, which used baseline total motor score as the predictor, demonstrated the best performance, with an area under the ROC curve of 0.869 (95% confidence interval: 0.826-0.911), a sensitivity of 75.5%, and a specificity of 88.5%. Moreover, the model was well calibrated across the full range of observed probabilities and displayed superior clinical benefit on the decision curve.
Conclusions:
A logistic regression model using baseline total motor score as a predictor of independent bowel function 1 year after SCI was successfully validated against an external dataset. These findings provide evidence supporting the use of this model to enhance the care for individuals with SCI.
