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Expedited COVID-19 vaccine trials: a rat-race with challenges and ethical issues

Prathamesh Haridas Kamble1, Siddharth Pramod Dubhashi2

  • 1Department of Physiology, All India Institute of Medical Sciences, Nagpur, India.

The Pan African Medical Journal
|September 23, 2020
PubMed

Insights

Global COVID-19 vaccine development faces ethical challenges. A global consortium is recommended to ensure ethical principles guide vaccine research and protect volunteers.

Area of Science:

  • Vaccinology
  • Bioethics
  • Global Health

Background:

  • Intense global efforts are underway to develop vaccines against COVID-19.
  • Over 160 candidate vaccines are in clinical trials worldwide, employing diverse targets and techniques.
  • The rapid vaccine development race presents significant ethical challenges and complexities.

Purpose of the Study:

  • To highlight the ethical issues in accelerated COVID-19 vaccine development.
  • To emphasize the importance of upholding fundamental ethical principles: autonomy, beneficence, non-maleficence, and justice.
  • To propose a framework for ethical oversight in vaccine research.

Main Methods:

  • Review of ethical considerations in rapid vaccine development.
  • Analysis of challenges including compressed timelines, resource management, volunteer risks, geopolitical factors, and misinformation.
  • Formulation of recommendations based on core ethical principles.

Main Results:

  • Accelerated vaccine development poses risks to research integrity and volunteer safety.
  • Ethical principles are at risk of being compromised due to the urgency.
  • Existing ethical guidelines may be insufficient for the current global health crisis.

Conclusions:

  • A global consortium is essential to establish and monitor a comprehensive ethical framework for vaccine development.
  • Upholding ethical principles is paramount to ensure public trust and safety.
  • Proactive ethical governance is critical for responsible innovation in vaccinology.
Keywords:
COVID-19ethicsvaccine

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