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Bone Marrow Burkitt Lymphoma in a Child
Matija Knežić1, Irena Seili Bekafigo2, Jelena Roganović3
1University of Rijeka, Faculty of Medicine, Braće Branchetta 20/1, 51000 Rijeka, Croatia.
Case Reports in Pathology
|September 23, 2020
Summary
Isolated bone marrow Burkitt lymphoma (BL) is a rare, aggressive cancer. Prompt diagnosis requires bone marrow aspiration, biopsy, flow cytometry, immunohistochemistry, and cytogenetics for effective treatment.
Area of Science:
- Hematology
- Pediatric Oncology
- Cancer Biology
Background:
- Burkitt lymphoma (BL) is a highly aggressive B-cell lymphoma.
- BL can present primarily in the bone marrow as extranodal disease.
- Isolated bone marrow involvement poses diagnostic challenges.
Observation:
- We present a case of a sporadic extranodal subtype of BL.
- The patient was an 11-year-old boy with disease exclusively in the bone marrow.
- Diagnosis required a comprehensive approach including bone marrow studies.
Findings:
- Isolated bone marrow involvement in BL is rare and diagnostically complex.
- A combination of bone marrow aspiration and biopsy is crucial.
- Flow cytometry, immunohistochemistry, and cytogenetics are essential for definitive diagnosis.
Implications:
- Early and accurate diagnosis of isolated bone marrow BL is critical for effective treatment.
- Standard diagnostic protocols must be adapted for extranodal presentations.
- This case underscores the importance of multi-modal diagnostic techniques in pediatric lymphoma.
