Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid Fabrication of Biomimetic Perfusable Structures via Lift-Up Viscous Fingering.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Competitive-adsorption-resistant interfacial regulation by 2-mercaptopyridine enables selective copper microvia superfilling.

Journal of colloid and interface science·2026
Same author

Corrigendum to 'Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells' [Biomaterials 72 (2015) 17043].

Biomaterials·2026
Same author

Transport of enzymatic activity across liquid-liquid interfaces using dynamic assemblies of magnetic particles via field-modulated interactions.

Nature communications·2026
Same author

A portable modular acoustic streaming vortex platform for flexible and robust fabrication of monodisperse micromaterials.

Lab on a chip·2026
Same author

A Smart Projective Imaging and Navigation System for Oral and Maxillofacial Surgery.

IEEE transactions on bio-medical engineering·2026

Related Experiment Video

Updated: Dec 8, 2025

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

21.6K

Performance Optimization of Microvalves Based on a Microhole Array for Microfluidic Chips.

Cuimin Sun1,2, Hui You1,3, Yang Xie1

  • 1Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui 230001, China.

Journal of Analytical Methods in Chemistry
|September 23, 2020
PubMed
Summary
This summary is machine-generated.

Optimized microhole array parameters in microfluidic chips enhance point-of-care testing (POCT) for tumor markers. This improves detection accuracy and efficiency by controlling reaction times and minimizing residual products.

More Related Videos

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices
10:18

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Published on: January 27, 2017

14.9K
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.4K

Related Experiment Videos

Last Updated: Dec 8, 2025

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

21.6K
Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices
10:18

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Published on: January 27, 2017

14.9K
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.4K

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Analytical Chemistry

Background:

  • Point-of-care testing (POCT) for tumor markers requires precise control over biochemical reactions.
  • Microfluidic devices offer potential for sensitive and efficient diagnostics but face challenges in reaction time control and sample handling.

Purpose of the Study:

  • To optimize microhole array parameters in a microfluidic chip's microvalve for enhanced POCT of tumor marker proteins.
  • To investigate the impact of microhole array geometry on fluid dynamics and residual liquid within the microvalve.

Main Methods:

  • Fabrication of microfluidic chips with microvalves featuring microhole arrays with varied structural parameters.
  • Conducting liquid flow experiments to quantify fluid rate and residual liquid in the microvalve region.
  • Analyzing the relationship between microhole dimensions (depth, diameter, center distance) and reaction product residuals.

Main Results:

  • Residual rate of reaction products is directly proportional to microhole depth and diameter.
  • Residual rate is inversely proportional to the distance between microhole centers.
  • Optimized parameters (95 μm depth, 230 μm diameter, 250 μm center distance) ensure sufficient delay time and minimize residual products.

Conclusions:

  • Optimized microhole array design significantly enhances microvalve performance in microfluidic chips.
  • This optimization leads to maximized detection efficiency and accuracy for tumor marker protein POCT.
  • The study provides a pathway for developing more sensitive and reliable microfluidic diagnostic devices.