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Updated: Dec 8, 2025
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
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Relapses in Patients Treated with High-Dose Biotin for Progressive Multiple Sclerosis
Sophie Mathais1, Xavier Moisset2,3, Bruno Pereira1
1CHU de Clermont-Ferrand, F-63000, Clermont-Ferrand, France.
Summary
High-dose biotin (HDB) does not increase relapse risk in progressive multiple sclerosis (PMS). Past relapse activity, not HDB, predicts future relapses in PMS patients.
Area of Science:
- Neurology
- Neuroimmunology
- Clinical Therapeutics
Background:
- High-dose biotin (HDB) is a proposed therapy for non-active progressive multiple sclerosis (PMS).
- Concerns exist regarding a potential association between HDB and increased relapse rates in PMS patients.
Purpose of the Study:
- To investigate whether HDB treatment elevates the risk of clinical relapse in PMS.
- To characterize patients experiencing relapses while on HDB therapy.
Main Methods:
- A multicenter, retrospective French study compared PMS patients on HDB with a matched control group.
- Poisson regression and propensity score weighting (IPTW) were used to analyze annualized relapse rates (ARR) and adjust for confounding factors.
Main Results:
- The study analyzed 2,628 HDB-treated patients and 654 controls over a median follow-up of 17 months.
- No significant difference in ARR was found between the HDB group (0.044 ± 0.23) and the control group (0.028 ± 0.16) (p=0.18).
- Pre-treatment relapse history, not HDB use, was identified as a predictor of relapse risk during treatment.
Conclusions:
- High-dose biotin treatment is not associated with an increased risk of clinical relapse in progressive multiple sclerosis.
- Patients with a history of higher relapse activity before treatment are more likely to experience relapses, irrespective of HDB use.
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