Related Experiment Video

Updated: Dec 8, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.9K

Different mother and daughter manifestations due to very high cholesterol-containing lipoproteins

J Hwang1, B Cheung, R C Block

  • 1University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. robert_block@urmc.rochester.edu.

European Review for Medical and Pharmacological Sciences
|September 23, 2020
PubMed

Insights

Familial hypercholesterolemia (FH) increases atherosclerotic cardiovascular disease (ASCVD) risk. Elevated lipoprotein(a) (Lp(a)) may worsen this risk, highlighting the need for Lp(a) screening in FH families.

Area of Science:

  • Genetics
  • Cardiology
  • Biochemistry

Background:

  • Familial hypercholesterolemia (FH) is an inherited disorder impacting LDL cholesterol metabolism.
  • FH significantly elevates the risk of premature atherosclerotic cardiovascular disease (ASCVD).
  • Elevated lipoprotein(a) (Lp(a)) is an emerging risk factor for ASCVD.

Observation:

  • A case series involving two Familial hypercholesterolemia patients, a mother and daughter, was analyzed.
  • The daughter exhibited a greater atherosclerotic cardiovascular disease burden compared to her mother.
  • This difference was attributed to the daughter's significantly higher lipoprotein(a) levels.

Findings:

  • Elevated lipoprotein(a) (Lp(a)) levels in Familial hypercholesterolemia (FH) patients correlate with increased atherosclerotic cardiovascular disease (ASCVD) risk.
  • Genetic predisposition and lipid profiles, including Lp(a), contribute to ASCVD severity in FH.

Implications:

  • Incorporating lipoprotein(a) (Lp(a)) testing into cascade screening for Familial hypercholesterolemia (FH) is crucial.
  • Early identification of elevated Lp(a) in FH relatives can guide proactive ASCVD risk management.
  • Personalized risk assessment in FH should consider both LDL-C and Lp(a) levels.
Abstract

More Related Videos

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

6.5K
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.6K

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.1K
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
1.6K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
473
Inflammation01:38

Inflammation

Overview
60.4K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.2K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
548