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HLA-DRB104:05* and HLA-DQB104:01*: Alleles Potentially Associated with Vogt-Koyanagi-Harada in Northern Thai Patients

Nampeung Anukul¹, Kessara Pathanapitoon², Nipapan Leetrakool³

¹Division of Transfusion Science, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.

Ocular Immunology and Inflammation

|September 23, 2020

Purpose:

To determine the frequency and association of alleles at human leukocyte antigen (HLA)-DRB1 and HLA-DQB1 loci in VKH disease patients from Northern Thailand.

Methods:

A case-control study was conducted with three subject groups: 23 VKH patients, 20 patients with other uveitis entities, and 40 healthy blood donors. HLA-DRB1 and HLA-DQB1 loci were analyzed and the frequency of HLA-DRB1 and HLA-DQB1 alleles was calculated by direct counting. The measure of association was calculated by odds ratio (OR) and 95% confidence interval.

Results:

In VKH patients, the most prevalent allele was HLA-DRB1*04:05, found in 35% of patients and with the highest OR (42.13). HLA-DQB1*04:01 was the next most prevalent, found in 23.91% of VKH patients. HLA-DQB1*05:02 was also detected in 23.91% of patients; however, a higher prevalence was observed in non-VKH and healthy controls (30% and 35%, respectively).

Conclusion:

HLA-DRB1*04:05 and HLA-DQB1*04:01 could be potential genetic markers for VKH.

Keywords:

Human Leukocyte Antigen Vogt-Koyanagi-Harada (VKH)disease association genetic marker uveitis

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