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; THE ADVANCEMENTS IN TREATMENT OF HIV-INFECTED PATIENTS WITH HERPETIC INFECTION
M Sokolenko1, L Sokolenko2, H Honchar2
11HSEI Bukovyna State Medical University; Ukraine.
Georgian Medical News
|September 23, 2020
Summary
Adding Allokin-alpha to standard valaciclovir therapy significantly improves outcomes for HIV-associated herpes infections. This combination shortens illness duration, reduces relapse frequency, and positively impacts immune markers like CD4+ cells and interleukins.
Area of Science:
- Immunology
- Virology
- Clinical Medicine
Background:
- HIV infection frequently leads to herpes infections.
- Standard antiviral therapy may not fully address immune dysregulation in these patients.
Purpose of the Study:
- To evaluate the efficacy of Allokin-alpha combined with valaciclovir in treating HIV-associated herpes infections.
- To assess the immunomodulatory effects of this combination therapy.
Main Methods:
- A study involving 47 patients with HIV-associated herpes infections.
- Basic therapy with valaciclovir supplemented by 6 subcutaneous injections of Allokin-alpha.
- Monitoring of clinical and immunological parameters.
Main Results:
- Combination therapy significantly shortened the duration of herpes infection manifestations.
- Reduced frequency and duration of relapses were observed.
- Positive immunomodulatory effects included decreased Interleukin-8 (IL-8) and Interleukin-10 (IL-10) levels, and a reduction in CD4+ lymphocytes at stage II HIV infection.
Conclusions:
- Allokin-alpha in combination with valaciclovir is an effective treatment for HIV-associated herpes infections.
- The treatment demonstrates significant immunoregulatory effects, aligning with clinical improvements.
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