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Kawasaki and COVID-19 disease in children: a systematic review

Laura Faustino Gonçalves1, Ana Inês Gonzales2, Fernanda Soares Aurélio Patatt3

  • 1. Graduanda em Fonoaudiologia pela Universidade Federal de Santa Catarina - UFSC, Florianópolis, SC, Brasil.

Revista Da Associacao Medica Brasileira (1992)
|September 23, 2020
PubMed

Insights

A systematic review found a potential link between COVID-19 and Kawasaki disease in children, noting increased incidence of severe Kawasaki-type illness during the pandemic. Further research is required to confirm this association.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Kawasaki disease (KD) is a pediatric vasculitis with unknown etiology.
  • The COVID-19 pandemic has been associated with various multisystem inflammatory syndromes in children.
  • Understanding potential links between infectious agents and KD is crucial for public health.

Purpose of the Study:

  • To systematically review scientific evidence evaluating the association between Kawasaki disease (KD) and COVID-19 in pediatric populations.
  • To synthesize findings on the incidence and characteristics of KD during the COVID-19 pandemic.

Main Methods:

  • A systematic literature review adhering to PRISMA guidelines was conducted.
  • Studies were identified using Medical Subject Heading (MeSH) terms.
  • Searches were performed in Medline (PubMed), LILACS, SciELO, Cochrane, and BIREME databases for articles published between 2010 and 2020.

Main Results:

  • Out of 840 retrieved articles, one study met the inclusion criteria for the review.
  • The included study reported a significant increase in Kawasaki-type disease incidence following the COVID-19 epidemic.
  • Findings suggest a potential association between the COVID-19 pandemic and a higher incidence of severe KD.

Conclusions:

  • Evidence suggests a possible link between the COVID-19 epidemic and an increased incidence of severe Kawasaki disease in children.
  • Further comprehensive studies are necessary to definitively establish and investigate the association between COVID-19 and Kawasaki disease.
Abstract

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