Cerebral regional oxygen saturation variability in neonates following cardiac surgery

Reduced cerebral regional oxygen saturation (crSO₂) variability in neonates, as measured by near-infrared spectroscopy, following cardiac surgery with deep hypothermic circulatory arrest (DHCA) is associated with poor neurodevelopmental outcomes. We sought to evaluate the variability of crSO₂ in a cohort of neonates following cardiac surgery with brief or no exposure to DHCA.

Variability of averaged 1-min crSO₂ values was calculated for the first 48 h following cardiac surgery in consecutive neonates over a 30-month period. Neonates requiring aortic arch repair underwent antegrade cerebral perfusion with either brief or no exposure to DHCA.

There were 115 neonates included in the study. Reduced crSO₂ variability was observed in neonates with aortic arch obstruction (p = 0.02) and non-survivors (p = 0.02). Post hoc analysis demonstrated that the reduction in crSO₂ variability was not as marked as in previously studied neonates with aortic arch obstruction who received DHCA alone (p < 0.001).

Neonates with aortic arch obstruction have reduced crSO₂ variability following cardiac surgery. The reduction in crSO₂ variability observed in aortic arch obstruction is likely influenced by a number of factors, including perioperative perfusion technique. The impact of interventions on crSO₂ variability and resultant influence on neurodevelopmental outcomes requires further study.

Neonates with aortic arch obstruction have reduced crSO₂ variability following cardiac surgery, which has been associated with poor neurodevelopmental outcomes, and is likely influenced by a number of factors, including perioperative perfusion technique. The contribution of perioperative perfusion technique to crSO₂ variability following neonatal cardiac surgery is significant. Monitoring of crSO₂ variability may provide insights into the adequacy of cerebral perfusion in neonates following cardiac surgery.