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Updated: Dec 8, 2025
09:12
A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
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Risk Factors Associated with Recurrent Clostridioides difficile Infection
Nicoleta Negrut1, Simona Bungau2, Tapan Behl3
1Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.
Healthcare (Basel, Switzerland)
|September 24, 2020
Summary
Recurrent Clostridioides difficile (CD) infections affect over half of patients, particularly older adults with multiple comorbidities. Identifying risk factors early can improve patient outcomes and reduce healthcare costs.
Area of Science:
- Infectious Diseases
- Epidemiology
- Clinical Medicine
Background:
- Clostridioides difficile (CD) causes significant nosocomial diarrhea, with recurrence leading to increased healthcare costs and patient risks.
- Identifying patients at high risk for recurrent Clostridioides difficile infection (CDI) is crucial for effective management.
Purpose of the Study:
- To quantify demographic, clinical, and treatment factors associated with Clostridioides difficile infection (CDI) recurrence.
- To identify predictive markers for CDI recurrence to inform preventative treatment strategies.
Main Methods:
- Retrospective analysis of 195 patients diagnosed with recurrent CDI between 2018-2019.
- Statistical analysis to determine associations between comorbidities (Charlson Comorbidity Index, cardiovascular, digestive, dementia, immunosuppressive) and CDI recurrence.
Main Results:
- The overall recurrence rate for CDI was 53.84% within three months of the initial episode.
- Patients aged 60-69 and those with higher Charlson Comorbidity Index scores were more frequently affected.
- Significant associations were found between CDI recurrence and cardiovascular, digestive, dementia, and immunosuppressive comorbidities.
Conclusions:
- Early identification of risk factors during the first CDI episode is essential for implementing targeted treatment strategies.
- Managing comorbidities may help reduce the incidence and impact of recurrent Clostridioides difficile infections.
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