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Changes of intestinal microflora in neonatal necrotizing enterocolitis: a single-center study
Miao Duan1, Zunhua Han2, Nanqu Huang3
1Department of Neonate, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou Province, China.
The Journal of International Medical Research
|September 24, 2020
Summary
Neonatal necrotizing enterocolitis (NEC) is linked to reduced intestinal flora diversity. Probiotic bacteria were less common in NEC patients, suggesting a role in disease development.
Area of Science:
- Microbiology
- Neonatal Medicine
- Gastroenterology
Background:
- Neonatal necrotizing enterocolitis (NEC) is a severe gastrointestinal emergency in premature infants.
- Intestinal microflora plays a critical role in infant gut health and development.
Purpose of the Study:
- To investigate alterations in intestinal microflora diversity and dynamics in neonates with NEC.
- To identify specific bacterial changes associated with NEC development and resolution.
Main Methods:
- Prospective study of 28 NEC patients and 30 controls (2016-2019).
- Fecal samples analyzed for species richness and Shannon's diversity index.
- Bacterial composition assessed using PCR-denaturing gradient gel electrophoresis.
Main Results:
- Significantly lower species richness and diversity index in NEC patients compared to controls.
- Increased prevalence of Bacteroides and Klebsiella in NEC group.
- Reduced detection of Escherichia coli, Bifidobacterium, and Lactobacillus in NEC patients.
- Intestinal bacteria normalized post-NEC resolution.
Conclusions:
- Decreased intestinal flora diversity, particularly reduced probiotic bacteria, may contribute to NEC pathogenesis.
- Restoration of gut microbiota may be important for NEC recovery.
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