Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Breast diseases and the internist.

F J Hendler

    The American Journal of the Medical Sciences
    |May 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Benign breast disease, particularly proliferative types with atypia, increases breast cancer risk. Current treatments manage symptoms but do not reduce cancer incidence in high-risk women.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Decreased expression of CD80 is a marker for increased tumorigenicity in a new murine model of oral squamous-cell carcinoma.

    International journal of cancer·1999
    Same author

    A region within murine chromosome 7F4, syntenic to the human 11q13 amplicon, is frequently amplified in 4NQO-induced oral cavity tumors.

    Oncogene·1997
    Same author

    Consistent allelic loss on mouse chromosome 7 distal to tyrosinase in 4-nitroquinoline-1-oxide-induced oral cavity tumors with loss of heterozygosity at Ha-ras-1.

    Molecular carcinogenesis·1997
    Same author

    Reverse transcriptase PCR in situ on cryopreserved tissue sections.

    Methods in molecular biology (Clifton, N.J.)·1997
    Same author

    Frequent DNA polymorphisms exist in inbred CBA/J and C3H/HeN mice.

    Genomics·1996
    Same author

    Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.

    Cancer research·1994
    Same journal

    Providers' Perspectives on Hospital-Based Tobacco Treatment Efforts.

    The American journal of the medical sciences·2026
    Same journal

    In Memoriam: Maurice A. Mufson, MD, MACP.

    The American journal of the medical sciences·2026
    Same journal

    Outcomes of Acute Myeloid Leukemia Patients Admitted to the Intensive Care Unit within 100 days of Allogeneic Hematopoietic Stem Cell Transplantation.

    The American journal of the medical sciences·2026
    Same journal

    Association Between Reverse Triiodothyronine and Cardiac Complications in Patients with Uncontrolled Graves' Disease.

    The American journal of the medical sciences·2026
    Same journal

    Chlorthalidone vs. hydrochlorothiazide in hypertension management: Lessons for guiding clinical practice.

    The American journal of the medical sciences·2026
    Same journal

    The impact of COVID-19 on alcohol-associated hepatitis and alcohol-associated cirrhosis.

    The American journal of the medical sciences·2026
    See all related articles

    Area of Science:

    • Oncology
    • Pathology
    • Endocrinology

    Background:

    • Benign breast disease (BBD) is common, affecting nearly all women.
    • Fibrocystic changes (benign mastopathies) are linked to increased breast cancer risk.
    • Proliferative BBD with atypia significantly elevates malignancy risk (up to 30%).

    Purpose of the Study:

    • To review the association between benign breast disease and breast cancer progression.
    • To discuss the role of hormonal factors in benign breast mastopathies.
    • To evaluate the efficacy of interventions in reducing cancer incidence in high-risk women.

    Main Methods:

    • Literature review of studies on benign breast disease and breast cancer.
    • Analysis of epidemiological data and risk factors.

    Related Experiment Videos

  • Evaluation of hormonal influences and therapeutic interventions.

    • Main Results:

    • Women with proliferative benign breast disease and atypia have a substantially higher risk of developing breast cancer.
    • These high-risk cases constitute a small percentage (3-5%) of all benign breast disease diagnoses.
    • Hormonal manipulations can alleviate symptoms like mastodynia and reduce biopsy rates.

    Conclusions:

    • Women with specific types of benign breast disease require enhanced screening and follow-up protocols.
    • The etiology of benign breast mastopathies is likely linked to endocrine responses.
    • Current therapeutic interventions do not demonstrably lower breast cancer incidence in high-risk populations.