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Arterial calcification at multiple sites: sex-specific cardiovascular risk profiles and mortality risk-the Rotterdam
Janine E van der Toorn1,2, Oscar L Rueda-Ochoa1,3, Niels van der Schaft1
1Department of Epidemiology, University Medical Centre, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Insights
Arteriosclerosis risk and mortality differ by sex and location. Blood pressure and smoking/cholesterol profiles are key risk factors, with specific arteries showing stronger associations in men and women.
Area of Science:
- Cardiovascular Disease Epidemiology
- Vascular Biology
- Biostatistics
Background:
- Arteriosclerosis burden varies by location and sex.
- Limited population data exists on sex-specific cardiovascular risk profiles and mortality linked to arteriosclerosis location.
Purpose of the Study:
- To assess sex-specific cardiovascular risk profiles and mortality risks associated with arteriosclerosis at various locations.
Main Methods:
- Utilized data from the Rotterdam Study (2357 participants).
- Quantified arteriosclerosis via computed tomography-assessed calcification in multiple arteries.
- Applied Principal Component Analysis (PCA) to identify sex-specific cardiovascular risk profiles.
- Employed sex-stratified regression models to analyze associations between risk profiles, calcification, and mortality.
Main Results:
- Identified three risk profiles (anthropometry/glucose/HDL, blood pressure, smoking/total cholesterol) in both sexes.
- Found distinct associations between risk profiles and severe calcification in women (e.g., blood pressure with carotid arteries) and men (e.g., blood pressure with vertebrobasilar arteries, smoking/cholesterol with aortic arch).
- Coronary artery calcification in men and extracranial carotid/aortic valve calcification in women showed strongest independent associations with cardiovascular mortality.
Conclusions:
- Findings confirm sex- and location-specific differences in arteriosclerosis etiology and consequences.
- Further research is needed to elucidate the distinct pathological processes underlying these observed differences in risk profiles.
Background:
Evidence has pointed towards differences in the burden of arteriosclerosis according to its location and sex. Yet there is a scarcity of population-based data on aggregated sex-specific cardiovascular risk profiles, instead of single risk factors, and mortality risk according to the location of arteriosclerosis. We assessed sex-specific cardiovascular risk profiles and mortality risk associated with arteriosclerosis.
Methods:
From the population-based Rotterdam Study, 2357 participants (mean age 69 years, 53% women) underwent non-contrast computed tomography to quantify calcification, as a proxy for arteriosclerosis, in the coronary arteries (CAC), aortic arch (AAC), extracranial (ECAC) and intracranial carotid arteries (ICAC), vertebrobasilar arteries (VBAC), and aortic valve (AVC). Principal component analysis (PCA) of eight distinct cardiovascular risk factors was performed, separately for women and men, to derive risk profiles based on the shared variance between factors. We used sex-stratified multivariable logistic regression to examine the associations between PCA-derived risk profiles and severe calcification at different locations. We investigated the associations of severe calcification with mortality risk using sex-stratified multivariable Cox regression.
Results:
PCA identified three cardiovascular risk profiles in both sexes: (1) anthropometry, glucose, and HDL cholesterol; (2) blood pressure; and (3) smoking and total cholesterol. In women, the strongest associations were found for profile 2 with severe ECAC and ICAC (adjusted OR [95% CI] 1.32 [1.14-1.53]) and for profile 3 with severe at all locations, except AVC. In men, the strongest associations were found for profile 2 with VBAC (1.31 [1.12-1.52]) and profile 3 with severe AAC (1.28 [1.09-1.51]). ECAC and AVC in women and CAC in men showed the strongest, independent associations with cardiovascular mortality (HR [95% CI] 2.11 [1.22-3.66], 2.05 [1.21-3.49], 2.24 [1.21-3.78], respectively).
Conclusions:
Our findings further underline the existence of sex- and location-specific differences in the etiology and consequences of arteriosclerosis. Future research should unravel which distinct pathological processes underlie differences in risk profiles for arteriosclerosis.
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