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Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
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Related Experiment Video

Updated: Dec 8, 2025

Electrochemotherapy of Tumours
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Electrolytes supplementation can decrease the risk of nephrotoxicity in patients with solid tumors undergoing

Omary M S Minzi1, Tatu E Lyimo2, Francis F Furia3

  • 1Department of Clinical Pharmacy and Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, P. O. Box 65013, Dar es Salaam, Tanzania. minziobejayesu@gmail.com.

BMC Pharmacology & Toxicology
|September 24, 2020
PubMed
Summary

Electrolyte supplementation significantly reduced cisplatin-induced kidney injury in cancer patients. This intervention lowered nephrotoxicity risk and improved survival, highlighting its potential clinical benefit.

Keywords:
CancerCisplatin, nephrotoxicitySerum creatinine, normal salineTriple electrolyte supplementation

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Area of Science:

  • Oncology
  • Nephrology
  • Pharmacology

Background:

  • Cisplatin is a vital chemotherapy agent for various cancers.
  • Cisplatin treatment is associated with significant nephrotoxicity, often linked to electrolyte imbalances.
  • Understanding and mitigating cisplatin-induced kidney damage is crucial for patient care.

Purpose of the Study:

  • To investigate the efficacy of triple electrolyte supplementation (Magnesium, Calcium, Potassium) in preventing cisplatin-induced nephrotoxicity.
  • To evaluate the impact of electrolyte supplementation on kidney function in cancer patients undergoing cisplatin-based chemotherapy.
  • To assess the effect of this supplementation on patient survival rates.

Main Methods:

  • A non-randomized interventional study was conducted at Ocean Road Cancer Institute.
  • Patients receiving cisplatin chemotherapy (≥50 mg) were divided into two groups: one received triple electrolyte supplementation with normal saline, the other received normal saline alone.
  • Nephrotoxicity was defined as serum creatinine elevation >1.5 times baseline, with measurements taken over a 4-week follow-up period.

Main Results:

  • The incidence of nephrotoxicity was substantially lower in the treatment group (20.41%) compared to the control group (54%).
  • Patients receiving electrolyte supplementation were 2.6 times less likely to develop nephrotoxicity (RR=2.6, P<0.0001).
  • Electrolyte supplementation was associated with improved survival rates and reduced nephrotoxicity incidence (HR=0.3149, P=0.0004).

Conclusions:

  • Triple electrolyte supplementation effectively reduces the risk of nephrotoxicity in patients treated with cisplatin-based chemotherapy.
  • The findings suggest that electrolyte supplementation may improve outcomes and survival in cancer patients receiving cisplatin.
  • Further validation through a larger, randomized controlled trial is recommended to confirm these promising results.