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Updated: Dec 8, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
Dysfunctional coupling of the parahippocampal cortex and inferior frontal gyrus during memory suppression in
Trevor Steward1, Pritha Das2, Gin S Malhi2
1Melbourne School of Psychological Sciences, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville 3010, Victoria, Australia.
Abstract:
The current study aimed to identify alterations in brain activation and connectivity related to memory suppression in posttraumatic stress disorder (PTSD) using the Think/No-Think paradigm during functional magnetic resonance imaging (fMRI). Reduced activation in the parahippocampal cortex during No-Think vs. Baseline trials was found in participants with PTSD compared to controls with no history of trauma (pFWE<0.05). Trauma-related intrusive memories (r = 0.562, p = 0.046) and avoidance behaviors (r = 0.636, p = 0.020) were positively correlated with parahippocampal cortex activation during memory suppression in the PTSD group. Psychophysiological interactions (PPI) analysis identified increased functional connectivity between the inferior frontal gyrus and the parahippocampus during memory suppression in the PTSD group compared to trauma-free controls (pFWE<0.05). Our findings support a network-based phenotype for altered memory suppression in individuals with PTSD rooted in dysfunctional parahippocampal-prefrontal coupling. These data validate neural models of PTSD and offer a novel neural circuit for brain-based interventions targeting trauma-related memory.
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