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Polyol and sugar osmolytes can shorten protein hydrogen bonds to modulate function

Jingwen Li1,2, Jingfei Chen1,2, Liaoyuan An1,2,3

  • 1Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China.

Communications Biology
|September 24, 2020
PubMed
Summary

Polyols and sugars, common in protein drugs, shorten protein backbone hydrogen bonds by competing with water. This subtle change enhances protein stability and function, as seen in protein binding.

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