Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid Catabolism01:25

Lipid Catabolism

609
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
609
Microbial Nutrition01:28

Microbial Nutrition

816
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
816
Microbial Fermentation01:23

Microbial Fermentation

1.0K
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
1.0K
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

1.1K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.1K
Environmental Applications of Microorganisms01:30

Environmental Applications of Microorganisms

723
Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
723
Carbon-dioxide Fixation01:28

Carbon-dioxide Fixation

461
Carbon dioxide fixation in prokaryotes enables the assimilation of inorganic carbon into organic molecules, supporting biosynthetic pathways, sustaining ecosystems, and contributing to the global carbon cycle. It also has industrial applications in carbon capture and bioproduct synthesis. Autotrophic organisms rely on this process to utilize CO₂ as a carbon source in diverse environments.The Calvin CycleThe Calvin cycle is the most widespread carbon fixation mechanism, primarily used by...
461

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of saccharin on insulin sensitivity in adult, overweight individuals without diabetes: a real-world pilot study.

Journal of the Endocrine Society·2026
Same author

Gut microbiota responses to bariatric surgery are associated with metabolic outcomes and type 2 diabetes remission.

Nature metabolism·2026
Same author

Discovery of metabolites produced by reactions between central carbon metabolites and cysteine that mark inflammatory macrophages.

bioRxiv : the preprint server for biology·2026
Same author

Multi-omic analysis reveals nitric oxide dependent remodeling in classically activated macrophages and identifies negative regulation mediated by AKR1A1.

bioRxiv : the preprint server for biology·2026
Same author

Multi-omic definition of metabolic obesity through adipose tissue-microbiome interactions.

Nature medicine·2026
Same author

GLP-1 from the distal gut is dispensable for body weight and glucose regulation but slows small intestinal transit in female mice.

American journal of physiology. Endocrinology and metabolism·2025

Related Experiment Video

Updated: Dec 8, 2025

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
06:58

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

7.4K

Gut microbial metabolites as multi-kingdom intermediates.

Kimberly A Krautkramer1, Jing Fan2, Fredrik Bäckhed3,4,5

  • 1Wallenberg Laboratory, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Nature Reviews. Microbiology
|September 24, 2020
PubMed
Summary

Microbial metabolites are key to host health, acting as signaling molecules. Understanding these gut microbiota outputs offers actionable targets for clinical and translational research.

More Related Videos

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.1K
Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources
12:47

Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources

Published on: January 22, 2018

9.8K

Related Experiment Videos

Last Updated: Dec 8, 2025

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
06:58

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

7.4K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.1K
Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources
12:47

Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources

Published on: January 22, 2018

9.8K

Area of Science:

  • Microbiome research
  • Metabolomics
  • Host-microbe interactions

Background:

  • Gut microbiota produces numerous metabolites influencing host physiology.
  • Metabolites act as signaling molecules and substrates in metabolic reactions.
  • Host-microbe interactions are complex due to extensive crosstalk.

Purpose of the Study:

  • To review the current knowledge on major microbial metabolite classes.
  • To emphasize clinical and translational implications of metabolite research.
  • To provide a framework for integrating metabolite discovery with mechanistic studies.

Main Methods:

  • Review of existing literature on microbial metabolites.
  • Overview of methodologies for measuring microbial metabolites.
  • Analysis of case studies demonstrating successful integration of approaches.

Main Results:

  • Identified actionable microbial targets relevant for host health.
  • Highlighted the role of metabolites as functional outputs of host-microorganism interactions.
  • Presented examples of progress in understanding host-microbiota interactions through metabolite studies.

Conclusions:

  • Metabolite-focused research provides critical insights into host-microbiota dynamics.
  • Further research is needed to fully elucidate mechanisms and clinical applications.
  • Integrating discovery and mechanistic studies is crucial for advancing the field.