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Primary Hyperparathyroidism: Experience from a Tertiary Care Centre in Pakistan
Tehseen Fatima1, Bhagwan Das2, Saadia Sattar3
1Dr. Tehseen Fatima, FCPS. Section of Endocrinology, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Pakistan Journal of Medical Sciences
|September 24, 2020
Summary
Primary hyperparathyroidism significantly impacts patients, often presenting with musculoskeletal and renal issues. Early diagnosis through screening and awareness can reduce associated morbidity.
Area of Science:
- Endocrinology
- Nephrology
- Surgical Pathology
Background:
- Primary hyperparathyroidism (PHPT) is a common endocrine disorder.
- It often leads to significant patient morbidity if not diagnosed and managed promptly.
Purpose of the Study:
- To investigate the clinical, biochemical, and radiological characteristics of PHPT.
- To evaluate management outcomes in patients with PHPT.
Main Methods:
- A retrospective study analyzing data from 103 patients with PHPT.
- Data collected from 2008 to 2017 at Aga Khan University Hospital, Karachi, Pakistan.
- Inclusion of clinical, biochemical, radiological, and histopathological findings.
Main Results:
- The study included 103 patients, with 80.6% being female, mean age 59.3 years.
- Musculoskeletal (58.3%) and renal (27.2%) manifestations were common; osteitis fibrosa cystica in 3.88%.
- Ultrasound and sestamibi scans localized lesions in 64.1% and 76.2% respectively. Surgery revealed adenoma in 84.8%, hyperplasia in 6.3%, and carcinoma in 2.53%. Disease recurrence was observed in 16.45%.
Conclusions:
- PHPT is linked to considerable morbidity in the studied population.
- Improving patient awareness, routine calcium screening, and vitamin D supplementation are crucial.
- A high index of clinical suspicion aids in early diagnosis and reduces morbidity.
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