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Research advances in myocardial injury caused by COVID-19

Jianjun Chen1, Yingfeng He1, Liangliang Zhou1

  • 1Department of Critical Care Medicine, Yancheng No.1 People's Hospital, Yancheng, China.

Cardiovascular Diagnosis and Therapy
|September 24, 2020
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, often leading to myocardial injury beyond respiratory symptoms. This study reviews COVID-19

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, emerged in late 2019.
  • SARS-CoV-2 exhibits high transmissibility, varied clinical presentations, and prolonged infectious incubation periods.
  • Emerging clinical data indicates myocardial injury in COVID-19 patients, alongside typical respiratory effects.

Purpose of the Study:

  • To summarize the clinical manifestations of myocardial injury in COVID-19 patients.
  • To explore potential mechanisms underlying COVID-19-induced myocardial injury.
  • To discuss current and future treatment strategies and research directions for cardiac complications in COVID-19.

Main Methods:

  • Systematic review and synthesis of published clinical data on COVID-19 patients.
  • Analysis of reported cases detailing myocardial injury in the context of SARS-CoV-2 infection.
  • Literature search for studies investigating the pathophysiology and treatment of cardiac manifestations.

Main Results:

  • COVID-19 patients frequently exhibit myocardial injury, characterized by specific clinical signs and symptoms.
  • Evidence suggests multiple potential mechanisms contributing to cardiac damage, including direct viral effects and inflammatory responses.
  • Various therapeutic approaches are being explored for managing myocardial injury in COVID-19.

Conclusions:

  • Myocardial injury is a significant clinical finding in COVID-19 patients.
  • Understanding the mechanisms of cardiac injury is crucial for effective treatment.
  • Further research is needed to optimize management strategies and improve outcomes for COVID-19 patients with cardiac involvement.

Keywords:
Coronavirus disease 2019 (COVID-19)diagnosismyocardial injurytreatment

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