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Plaque imaging volume analysis: technique and application
Alessandro Murgia1, Antonella Balestrieri1, Marco Francone2
1Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari - Polo di Monserrato, s.s. 554 Monserrato (Cagliari) 09045, Italy.
Insights
Atherosclerosis management is challenging. Research now focuses on vulnerable carotid plaque features, not just stenosis, for predicting cerebrovascular events.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Medical Imaging
Background:
- Atherosclerosis, particularly in carotid arteries, is a major cause of ischemic stroke.
- Traditional focus on stenosis degree is shifting towards identifying vulnerable plaque characteristics.
- Understanding plaque vulnerability is crucial for predicting recurrent cerebrovascular events.
Purpose of the Study:
- To review current research on carotid atherosclerotic disease.
- To highlight imaging modalities for carotid plaque characterization.
- To assess the clinical impact of these diagnostic tools.
Main Methods:
- Literature review of carotid atherosclerotic disease research.
- Analysis of imaging techniques used for carotid plaque assessment.
- Evaluation of the clinical utility of plaque vulnerability imaging.
Main Results:
- Vulnerable plaque features are emerging as key predictors of cerebrovascular events.
- Advanced imaging modalities offer insights into plaque composition and stability.
- Clinical application of plaque imaging is evolving to guide patient management.
Conclusions:
- Shifting focus to plaque vulnerability improves prediction of cerebrovascular events.
- Imaging plays a critical role in assessing carotid plaque and guiding clinical decisions.
- Further research and integration of imaging are essential for managing carotid atherosclerosis.
Abstract:
The prevention and management of atherosclerosis poses a tough challenge to public health organizations worldwide. Together with myocardial infarction, stroke represents its main manifestation, with up to 25% of all ischemic strokes being caused by thromboembolism arising from the carotid arteries. Therefore, a vast number of publications have focused on the characterization of the culprit lesion, the atherosclerotic plaque. A paradigm shift appears to be taking place at the current state of research, as the attention is gradually moving from the classically defined degree of stenosis to the identification of features of plaque vulnerability, which appear to be more reliable predictors of recurrent cerebrovascular events. The present review will offer a perspective on the present state of research in the field of carotid atherosclerotic disease, focusing on the imaging modalities currently used in the study of the carotid plaque and the impact that such diagnostic means are having in the clinical setting.
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