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On the Relativity of Dipyridamole and Dobutamine Flows

Heinrich R Schelbert1

  • 1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Box 95648, B2-085J, 650 Charles E Young Drive South, Los Angeles, CA, 90095-6948, USA. hschelbert@mednet.ucla.edu.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|September 24, 2020
PubMed
Abstract

No abstract available in PubMed .

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Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
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