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A randomised crossover trial of closed loop automated oxygen control in preterm, ventilated infants

Sarah Sturrock1, Hemant Ambulkar1, Emma E Williams1

  • 1Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Acta Paediatrica (Oslo, Norway : 1992)
|September 24, 2020
PubMed

Insights

Closed loop automated oxygen control significantly reduced prolonged desaturation episodes in preterm infants. This system also increased time spent within the target oxygen saturation range, improving respiratory support.

Area of Science:

  • Neonatal Medicine
  • Pediatric Respiratory Care
  • Medical Technology

Background:

  • Preterm infants often experience desaturation episodes, posing risks to their health.
  • Current standard care for oxygenation in ventilated preterm infants requires frequent manual adjustments.
  • Automated oxygen control systems aim to improve stability and reduce complications.

Purpose of the Study:

  • To evaluate the efficacy of closed-loop automated oxygen control in preterm infants.
  • To assess the impact on desaturation duration and severity.
  • To determine changes in the need for blood gases and chest radiographs.

Main Methods:

  • A randomized crossover study design was employed.
  • Infants received standard care and automated oxygen control on separate days.
  • Data collected included desaturation events, time within target SpO2 range, and manual oxygen adjustments.

Main Results:

  • Automated oxygen control led to fewer desaturations lasting over 30 and 60 seconds.
  • Infants spent a significantly higher proportion of time within their target SpO2 range.
  • Manual adjustments to inspired oxygen concentration were drastically reduced with automated control.

Conclusions:

  • Closed-loop automated oxygen delivery effectively reduces prolonged desaturations in preterm infants.
  • This technology enhances time spent within the targeted oxygen saturation range.
  • Automated systems offer a promising approach to optimize respiratory support in neonates.
Abstract

Keywords:
closed loop automated oxygen deliverydesaturationhyperoxia

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