Related Experiment Video
Updated: Dec 8, 2025
Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
Published on: May 10, 2021
Postoperative radiotherapy is associated with improved overall survival for alveolar ridge squamous cell carcinoma
Corbin D Jacobs1, Hannah Williamson2, Ian Barak2
1Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA.
Background:
Alveolar ridge squamous cell carcinoma (ARSCC) is poorly represented in randomized trials.
Methods:
Adults in the National Cancer Database diagnosed with ARSCC between 2010 and 2014 who should be considered for postoperative radiotherapy (PORT) based on National Comprehensive Cancer Network (NCCN)-defined risk factors were identified.
Results:
Eight hundred forty-five (58%) of 1457 patients meeting the inclusion criteria received PORT. PORT was associated with improved overall survival (OS) on unadjusted (hazard ratio [HR] 0.83, 95% confidence interval [CI] 0.70-0.98, P = .02) and multivariable (HR 0.78, 95% CI 0.64-0.94, P = .002) analyses. PORT was associated with significantly improved 5-year OS for patients with 1 (68% vs 58%, P < .001), 2 (52% vs 31%, P < .001), and ≥3 (38% vs 24%, P < .001) NCCN-defined risk factors. Prognostic variables significantly associated with worse OS on multivariable analysis included advanced age, primary tumor size ≥3 cm, high grade, positive margin(s), stage N2-3, level IV/V nodal metastasis, and extranodal extension.
Conclusion:
PORT for resected ARSCC with adverse pathologic features is associated with significantly improved OS.
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