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Updated: Dec 8, 2025
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for
Daniel Joss1, Florine Winter, Daniel Häussinger
1Department of Chemistry, University of Basel, St. Johanns-Ring 19, Basel 4056, Switzerland. daniel.haeussinger@unibas.ch.
Abstract:
Herein, a novel and rationally designed ortho-substituted pyridine activator is reported that reacts rapidly and selectively with cysteine thiols. It forms reduction-stable conjugates and induces large pseudocontact shifts, residual dipolar couplings and paramagnetic relaxation enhancement on both ubiquitin S57C and human carbonic anhydrase II S50C constructs under physiological conditions.
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