Related Experiment Video
Updated: Dec 8, 2025

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
[Light - darkness and bipolar disorder]
Françoise Jermann1, Hélène Richard-Lepouriel1, Jean-Michel Aubry1
1Service des spécialités psychiatriques, Département de psychiatrie, HUG, 1211 Genève 14.
Abstract:
Circadian rhythmicity generated by the biological clock structures the functioning of human beings over a period of almost 24 hours. This clock is entrained daily by internal and external cues among which light is the most powerful. Several disturbances, whether clinical or biological, observed in bipolar disorders are suggestive of a disruption of the circadian rhythm. Thus, treatments that modulate the biological clock have been developed. So far, the results of light therapy are not unanimous and invite us to better specify the treatment modalities. Dark therapy is a promising intervention that is still not much studied nowadays and therefore opens up great prospects for research in the future.
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