Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thrombolysis and stroke. Past and future.

M A Sloan

    Archives of Neurology
    |July 1, 1987
    PubMed
    Summary

    Thrombolytic therapy, once unfavorable, is now a safe and effective treatment for acute stroke. Advances in clot-specific agents and patient selection minimize risks like brain hemorrhage.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Transcranial doppler findings during spontaneous recanalization of vertebrobasilar occlusions.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
    Same author

    Assessment: transcranial Doppler ultrasonography: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

    Neurology·2004
    Same author

    Clinical features of cardioembolic strokes identified by transesophageal echocardiography.

    Neurology India·2001
    Same author

    Alcohol intake, type of beverage, and the risk of cerebral infarction in young women.

    Stroke·2001
    Same author

    Distribution and correlates of elevated total homocyst(e)ine: the Stroke Prevention in Young Women Study.

    Annals of epidemiology·2000
    Same author

    Lipoprotein (a) and the risk of ischemic stroke in young women.

    Atherosclerosis·2000

    Area of Science:

    • Neurology
    • Cardiovascular Medicine
    • Pharmacology

    Background:

    • Previous attempts to limit ischemic cerebral infarct size yielded mixed results.
    • Thrombolytic (fibrinolytic) therapy historically had unfavorable outcomes.
    • Advances in neuroimaging and understanding of ischemia pathophysiology enable new interventions.

    Purpose of the Study:

    • To evaluate the feasibility and safety of thrombolytic therapy in acute stroke.
    • To assess the risks and benefits of fibrinolytic agents in stroke patients.
    • To highlight the role of clot-specific agents in modern stroke treatment.

    Main Methods:

    • Review of historical and recent clinical data on thrombolytic therapy for stroke.
    • Analysis of factors influencing hemorrhagic transformation of ischemic infarcts.
    • Evaluation of patient selection criteria for fibrinolytic treatment.

    Main Results:

    • Thrombolytic therapy is now a feasible pharmacologic intervention for acute stroke.
    • Central nervous system hemorrhage is a rare complication, especially compared to acute myocardial infarction treatment.
    • Risk of hemorrhagic transformation is linked to infarct size, location, and patient age.

    Conclusions:

    • Careful patient selection and clot-specific agents like tissue-type plasminogen activator improve safety.
    • Fibrinolytic therapy is potentially effective for acute ischemic stroke.
    • Anticoagulation may increase infarct size but not the likelihood of hemorrhagic transformation.

    Related Experiment Videos