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Stabilized Ortho-Silicic Acid as a Modifier of Tissue-Preliminary Comparative Biomaterial Studies
Journal of Biomedical Nanotechnology
|September 24, 2020
Summary
Ortho-silicic acid (OSA) effectively modifies human tissues, including skin and amniotic membranes. This silicon source shows potential for developing new regenerative therapies and dietary supplements.
Area of Science:
- Biochemistry
- Biomaterials Science
- Tissue Engineering
Background:
- Monomeric ortho-silicic acid (H₄SiO₄) is the most bioavailable silicon source for human cells.
- Silicon plays a crucial role in delivering nutrients to body cells.
Purpose of the Study:
- To investigate the modification of human tissues (amnion, burn skin) and serum by ortho-silicic acid (OSA).
- To explore the potential of OSA in developing innovative regenerative therapies.
Main Methods:
- Fourier-transform infrared (FTIR) spectroscopy was used to analyze molecular-level changes in OSA-modified tissues.
- Microbiological studies assessed the anti-inflammatory and antibacterial properties of modified skin and amniotic samples against common bacteria.
Main Results:
- OSA treatment induced significant molecular changes in tissues, evidenced by the appearance of a Si-O-Si band at 1085 cm⁻¹ at an optimal 1:6000 OSA concentration.
- Modified skin and amniotic samples exhibited moderate resistance to *Enterococcus faecalis*, *Staphylococcus aureus*, and *Escherichia coli* (0.5-4 mm inhibition zones).
Conclusions:
- Ortho-silicic acid effectively modifies human tissues at a molecular level.
- OSA-treated tissues demonstrate potential for developing novel active dressings or dietary supplements to enhance tissue regeneration.
