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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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First trimester elevations of hematocrit, lipid peroxidation and nitrates in women with twin pregnancies who develop

David Ramiro-Cortijo1, María de la Calle2, Pilar Rodriguez-Rodriguez3

  • 1Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard School of Medicine, Boston, MA, USA; Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.

Pregnancy Hypertension
|September 24, 2020
PubMed

Twin pregnancies are considered a risk factor for preeclampsia, an obstetric complication with high maternal and infant morbi-mortality. We hypothesize that alterations in maternal hematocrit, plasma lipid peroxidation and nitrates in the first trimester of pregnancy are associated with preeclampsia development in twin pregnancies. Blood samples were extracted from 102 healthy women with twin pregnancies at tenth week of gestation to assess hematological parameters and plasma levels of malondialdehyde and nitrates. Logistic regression model showed an association between red blood cells (OR = 38.8; p-value = 0.009), hematocrit (OR = 1.6; p-value = 0.017), malondialdehyde (OR = 1.5; p-value = 0.002), and nitrates (OR = 1.1; p-value = 0.045) and preeclampsia development. These parameters are potential biomarkers for early preeclampsia detection in twin pregnancies. Future research is needed to assess their value in predictive algorithms.

Keywords:
BiomarkersMalondialdehydeNitric OxidePreeclampsiaTwin pregnancy

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