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Updated: Dec 7, 2025

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans
Published on: December 9, 2022
The Lipidome Fingerprint of Longevity
Mariona Jové1, Natàlia Mota-Martorell1, Irene Pradas1
1Department of Experimental Medicine, Lleida University (UdL), Lleida Biomedical Research Institute (IRBLleida), 25198 Lleida, Spain.
Abstract:
Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal species-humans included-demonstrate that both the cell membrane fatty acid profile and lipidome are a species-specific optimized evolutionary adaptation and traits associated with longevity. All these emerging observations point to lipids as a key target to study the molecular mechanisms underlying differences in longevity and suggest the existence of a lipidome profile of long life.
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