Related Experiment Video

Updated: Dec 7, 2025

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
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Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

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Is it really a seizure? The challenge of paroxysmal nonepileptic events in young infants

Seung Yeon Jung1, Joon Won Kang2

  • 1Department of Pediatrics, Chungnam National University Hospital, Daejeon, Korea.

Clinical and Experimental Pediatrics
|September 25, 2020
PubMed

Insights

Paroxysmal nonepileptic events (PNE) in infants are often physiological and benign. Accurate diagnosis using video analysis helps differentiate from epilepsy, reassuring caregivers as symptoms typically resolve with age.

Area of Science:

  • Pediatrics
  • Neurology

Background:

  • Paroxysmal nonepileptic events (PNE) encompass diverse nonepileptic behaviors in infants.
  • Physiologic PNE constitute the majority of these events in infants.

Purpose of the Study:

  • To highlight the importance of accurate diagnosis of PNE in infants.
  • To differentiate PNE from epilepsy through diagnostic methods.

Main Methods:

  • Caregiver-provided video clip analysis for diagnosis.
  • Differential diagnosis of epilepsy using blood tests, electroencephalography (EEG), and imaging.

Main Results:

  • Most PNE exhibit benign progression.
  • Symptoms of PNE commonly improve with age and without specific intervention.

Conclusions:

  • Accurate diagnosis of PNE is crucial for appropriate management and reassurance of caregivers.
  • Distinguishing PNE from epilepsy is essential for effective care planning.

Keywords:
ElectroencephalographyEpilepsyInfantNonepileptic seizureSeizure

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