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Targeting STAT3 in Cancer Immunotherapy

Sailan Zou1, Qiyu Tong1, Bowen Liu2

  • 1Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, Sichuan, China.

Molecular Cancer
|September 25, 2020
PubMed

Insights

Signal transducer and activator of transcription 3 (STAT3) is crucial in cancer immune evasion. Targeting STAT3 offers a promising therapeutic strategy for developing more effective cancer treatments.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Signal transducer and activator of transcription 3 (STAT3) is a key regulator of the anti-tumor immune response.
  • STAT3 hyperactivation in cancer cells and the tumor microenvironment promotes immunosuppression.
  • Targeting STAT3 is a promising strategy for cancer therapy.

Purpose of the Study:

  • To review the role of STAT3 signaling in tumorigenesis and immune regulation.
  • To highlight the current development of STAT3-targeting therapeutics.
  • To discuss recent advances in STAT3-based combination immunotherapy.

Main Methods:

  • Literature review of STAT3 signaling in cancer.
  • Analysis of current STAT3-targeting therapeutic approaches.
  • Summary of STAT3-based combination immunotherapy strategies.

Main Results:

  • STAT3 plays a central role in inhibiting immune activation and promoting immunosuppression in cancer.
  • Various STAT3-targeting agents are under development.
  • Combination immunotherapies involving STAT3 inhibition show promise.

Conclusions:

  • STAT3 signaling is a critical target for overcoming cancer immune evasion.
  • STAT3-based therapies, particularly in combination, offer potential for improved cancer treatment outcomes.
  • Further research into translational applications of STAT3 is warranted.
Keywords:
CAR-TCancerImmune checkpoint blockadeImmunosuppressionImmunotherapySTAT3

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