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Updated: Dec 7, 2025

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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Selinexor, selective inhibitor of nuclear export: Unselective bullet for blood cancers

Katerina Benkova1, Jana Mihalyova1, Roman Hajek1

  • 1Department of Hematooncology, University Hospital Ostrava, 17. listopadu 1790/5, Ostrava 708 52, Czech Republic; Faculty of Medicine, University of Ostrava, Ostrava 703 00, Czech Republic.

Blood Reviews
|September 25, 2020
PubMed

Insights

Exportin 1 (XPO1) inhibitors, like selinexor, show promise in treating cancers by restoring tumor suppressor function. This review covers selinexor and newer SINE compounds for lymphoid and myeloid malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Exportin 1 (XPO1) is crucial for transporting tumor suppressors and oncoproteins.
  • XPO1 upregulation is linked to cancer progression and poor prognosis.
  • Selective inhibitors of nuclear export (SINE) offer a targeted cancer therapy approach.

Purpose of the Study:

  • To review the knowledge of selinexor and next-generation SINE compounds.
  • To discuss their application in lymphoid and myeloid malignancies.

Main Methods:

  • Comprehensive literature review of XPO1 inhibitors.
  • Analysis of clinical trial data for selinexor.
  • Evaluation of SINE compounds in hematological malignancies.

Main Results:

  • Selinexor is the first-in-class SINE compound, approved for multiple myeloma and diffuse large B-cell lymphoma.
  • SINE compounds demonstrate targeted anti-cancer activity.
  • Ongoing research explores next-generation SINEs for broader applications.

Conclusions:

  • Selinexor and other SINEs represent a significant advancement in cancer therapy.
  • Further investigation into SINE compounds is warranted for lymphoid and myeloid malignancies.
Keywords:
Exportin 1 proteinLeukemiaLymphomaMyelomaSelective inhibitors of nuclear exportSelinexor

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