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Published on: December 6, 2016
Cardiovascular issues in obstructive sleep apnoea in children: A brief review
Marcella Gallucci1, Monica Gessaroli1, Gabriele Bronzetti2
1Department of Paediatrics, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Insights
Obstructive sleep apnoea (OSA) in children can lead to serious cardiovascular issues. This review examines the early and late cardiac changes associated with paediatric OSA.
Area of Science:
- Pediatric Cardiology
- Sleep Medicine
- Cardiovascular Health
Background:
- Obstructive sleep apnoea (OSA) is prevalent in children (1-6%).
- OSA causes airway occlusion during sleep, leading to arousal and disrupted sleep.
- It is linked to neurocognitive deficits and altered gas exchange.
Purpose of the Study:
- To review early and late cardiological changes in children with OSA.
- To highlight the impact of apnoeic events on the paediatric cardiovascular system.
Main Methods:
- Literature review of recent findings.
- Focus on paediatric population.
Main Results:
- OSA can trigger cardiovascular complications via sympathetic nervous system activation.
- Inflammatory and oxidative stress pathways are implicated.
- Increased risk of systemic hypertension in affected children.
Conclusions:
- Cardiovascular effects of OSA can manifest early in life.
- Understanding these changes is crucial for paediatric cardiac care.
- Further research into early detection and intervention is warranted.
Abstract:
Obstructive sleep apnoea (OSA) is a very common disease with a prevalence that ranges from 1% to 6% in children. It is characterized by intermittent partial or complete occlusion of the upper airway during sleep, leading to recurrent arousals and disturbed sleep architecture, to neurocognitive disorders and alterations in homeostatic gas exchange. Cardiovascular complications may develop in children with OSA through various mechanisms including activation and dysregulation of the sympathetic nervous system, induction of pro-inflammatory and pro-oxidant status and increased risk of systemic hypertension. As the deleterious effects of OSA on the cardio-vascular system may start early in life, in this brief review we focused our attention both on early and late cardiological changes induced by apnoeic events in the paediatric population, by reviewing recent findings in the literature.
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