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Related Experiment Video

Updated: Dec 7, 2025

Microfluidics in Assessing Platelet Function
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Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on

Jason Philip Appleton1,2, Carla Richardson1,2, Natalia Dovlatova3,4

  • 1Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.

Stroke and Vascular Neurology
|September 25, 2020
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Summary

Approximately 11% of patients taking clopidogrel exhibited resistance to the antiplatelet medication. This clopidogrel resistance was not significantly associated with a higher risk of recurrent cerebrovascular events in the study population.

Keywords:
stroke

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Cardiology

Background:

  • Antiplatelet agents are crucial for reducing recurrent cerebral ischemia.
  • Treatment resistance to antiplatelet drugs like clopidogrel affects patient outcomes.
  • Understanding clopidogrel insensitivity is key to improving stroke prevention.

Purpose of the Study:

  • To determine the proportion of patients resistant to clopidogrel.
  • To investigate the link between clopidogrel insensitivity and recurrent cerebrovascular events.

Main Methods:

  • Recruited patients with recent non-cardioembolic ischemic stroke or TIA on clopidogrel.
  • Assessed platelet function via remote measurement of P-selectin (CD62P) expression.
  • Collected data on recurrent vascular events at least 90 days post-enrollment.

Main Results:

  • 11.3% of patients demonstrated resistance to clopidogrel.
  • No significant association was found between clopidogrel resistance and recurrent ischemic events.
  • Aspirin resistance was not observed in patients taking both aspirin and clopidogrel.

Conclusions:

  • Remote platelet function assessment using P-selectin is a feasible method.
  • A notable percentage of patients show resistance to clopidogrel.
  • Current findings do not establish a significant link between clopidogrel resistance and event recurrence.