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Clinical Presentation of Patients Infected with Coronavirus Disease 19: A Systematic Review

Tadesse Sheleme1, Firomsa Bekele1, Tasissa Ayela1

  • 1Department of Pharmacy, College of Public Health and Medical Science, Mettu University, Mettu, Ethiopia.

Infectious Diseases
|September 25, 2020
PubMed

Insights

Fever, cough, fatigue, and shortness of breath are the most common symptoms of coronavirus disease 2019 (COVID-19). This systematic review summarizes the clinical presentations of COVID-19 patients.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Epidemiology

Background:

  • Coronavirus disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization.
  • The highly contagious nature of the virus has led to rapid global spread and increasing case numbers and mortality rates.
  • Understanding the clinical presentation of this emerging disease is crucial for public health response.

Purpose of the Study:

  • To systematically review and summarize the clinical presentations of patients with coronavirus disease 2019 (COVID-19).

Main Methods:

  • A systematic review of published articles was conducted using PubMed, Scopus, and Google Scholar.
  • Searches were performed between April 18-25, 2020, including terms like "COVID-19" and "severe acute respiratory syndrome coronavirus 2."
  • Included studies were in English, with full-text availability, and encompassed cross-sectional, case-control, cohort, and case series designs.

Main Results:

  • Thirty studies with 4829 participants were included in the review.
  • The age range of infected patients was 0.25 to 94 years.
  • The most frequently reported clinical symptoms were fever (77.6%), cough (64.8%), fatigue (27.2%), dyspnea (21.2%), and sputum production (18.0%).

Conclusions:

  • Fever, cough, fatigue, and dyspnea are the most common clinical features of COVID-19.
  • A comprehensive understanding of the clinical spectrum of COVID-19 is vital for effective management and prevention, particularly for healthcare professionals.
Abstract

Keywords:
COVID-19Coronavirus disease 19clinical presentationsystematic review

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