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Updated: Dec 7, 2025

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
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In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling

Published on: November 3, 2015

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Measurement, Analysis and Interpretation of Pressure/Flow Waves in Blood Vessels

Jonathan P Mynard1,2,3,4, Avinash Kondiboyina1,2, Remi Kowalski1,2,4

  • 1Heart Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.

Frontiers in Physiology
|September 25, 2020
PubMed

Insights

Wave analysis examines blood pressure and flow waveforms to understand cardiovascular biomechanics. This review introduces key concepts and practical applications of techniques like pulse wave analysis for disease insights.

Area of Science:

  • Cardiovascular Biomechanics
  • Physiology
  • Medical Engineering

Background:

  • Cardiovascular system function relies on complex biomechanical interactions.
  • Disease impairs cardiovascular performance through disrupted interactions.
  • 'Wave analysis' techniques scrutinize pressure and flow waveforms to reveal these interactions.

Purpose of the Study:

  • To provide a comprehensive introduction to wave analysis techniques.
  • Focus on key concepts and practical applications, not mathematical derivations.
  • To review methods for signal acquisition and waveform decomposition.

Main Methods:

  • Overview of invasive and non-invasive measurement techniques for signal acquisition.
  • Review of pulse wave analysis, wave separation, and wave intensity analysis.
  • Discussion of methods for estimating wave speed and characteristic impedance.

Main Results:

  • Wave analysis offers insights into cardiovascular biomechanical interactions.
  • Understanding wave generation and modulation is critical for interpreting patterns.
  • Key techniques enable decomposition of waveforms into forward and backward components.

Conclusions:

  • Wave analysis is a valuable tool for studying cardiovascular health and disease.
  • The review covers fundamental concepts, practical applications, and emerging techniques.
  • Further exploration of wave potential and reservoir-excess pressure approaches is noted.

Keywords:
haemodynamicspulse wave analysisreservoir pressurewave intensity analysiswave separationwave speed

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