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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Related Experiment Video

Updated: Dec 7, 2025

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
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Research Progress in Atopic March.

Lan Yang1, Jinrong Fu1, Yufeng Zhou1,2

  • 1Institute of Pediatrics, Children's Hospital of Fudan University, The Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Frontiers in Immunology
|September 25, 2020
PubMed
Summary
This summary is machine-generated.

The atopic march describes the progression of allergic diseases from infancy to childhood. Understanding this pattern is key for predicting and treating conditions like eczema, food allergies, asthma, and allergic rhinitis.

Keywords:
allergic rhinitisasthmaatopic dermatitisatopic marchfood allergy

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Area of Science:

  • Immunology
  • Pediatrics
  • Allergy Research

Background:

  • Rising incidence of allergic diseases globally.
  • The atopic march phenomenon: a temporal sequence of allergic disease development.
  • Incomplete understanding of underlying mechanisms and influencing factors.

Purpose of the Study:

  • To review the epidemiology of the atopic march.
  • To explore associated allergic diseases.
  • To discuss mechanistic studies and treatment strategies.

Main Methods:

  • Literature review of cross-sectional and longitudinal studies.
  • Analysis of temporal disease progression.
  • Synthesis of current research on atopic march.

Main Results:

  • Allergic diseases follow a predictable order: atopic dermatitis/food allergy to asthma/allergic rhinitis.
  • Genetic and environmental factors may modulate the atopic march.
  • Mechanisms require further elucidation.

Conclusions:

  • The atopic march concept offers a framework for research and clinical practice.
  • Improved understanding can enhance prediction and prevention of allergic diseases.
  • Novel treatment strategies are needed for effective management.